What tests are available?įortunately a reliable test exists for PK deficiency. While mating carrier cats together or carrier and affected cats together will always carry a risk of producing affected kittens, a carrier cat can be safely mated with a health non-carrier normal cat (carrying a pair of completely normal genes) as in this case none of the offspring will be affected (although around 1 in 2 will be carriers). Since carrier cats remain healthy though, and since affected cats may not necessarily be detected until they are a few years of age, the potential exists for both carrier and affected cats to have significant numbers of litters before the disease is identified. If only one gene is defective and one is normal (this would be called a heterozygote) the normal gene is ‘dominant’ over the abnormal ‘recessive’ gene and the cat will only be a carrier of the defect but will not develop any signs or disease.Īffected cats (homozygous – having two copies the same – for the abnormal gene) arise when affected or carrier cats are mated with each other.
This means that both genes have to be defective for a cat to develop PK deficiency. The disease is inherited as an autosomal recessive trait (see diagram). How is PK deficiency inherited?Ī single pair of genes is responsible for development of PK deficiency. Although PK deficiency is hereditary, because the anaemia is often mild and intermittent clinical signs may not necessarily be noticed until the cat is quite old. However, a rapid severe life-threatening anaemia can also develop. Most of the time the anaemia is either occurs very slowly or occurs mildly, enabling the cat to adapt to the lower number of red blood cells and not show any obvious clinical signs.Īnaemia itself often results in only vague signs such as lethargy and lack of appetite. However, since the body can quickly produce new red blood cells (in the bone marrow), the anaemia is usually only intermittently detectable. The main consequence of PK deficiency is the development of anaemia. If this enzyme is lacking, the lifespan (survival time) of the red blood cells is significantly reduced, resulting in a reduction in the number of red blood cells in the circulation (anaemia). Pyruvate kinase is an enzyme found within red blood cells (erythrocytes) in the circulation, which enables them to produce energy to survive. I just wanted to raise the awareness of purchasing from PK and would appreciate someone can help me or provide a solution for me.Pyruvate kinase (PK) deficiency is an inherited disease occasionally encountered in Abyssinian and Somali cats, and also reported rarely in the domestic shorthair cat.
Dude, i trusted PK so much since the community are highly recommending PK for a newbie's first order and ended up getting a wrong insole.
But Kim refused to send me the correct insoles and only offered discount for my next order with extra insoles in it. The shipping fee is not that high tho since I'm just living in Malaysia. So I emailed kim from PK to ask them to send me the correct insoles or at least provide a solution. They sent me the wrong size of insoles for the left side LOLL (the right side is correct tho). Payment process was smooth but after waiting for 2 weeks, there's a problem. I decided to purchase my first pair of yeezy 350v2 blue tint from PK. So I'm new to this community and I loved it.
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