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In contrast to the many studies on the position of pseudopod extension, the timing of pseudopod extension is less frequently studied.
These signaling pathways are regulated by internal factors in polarized cells and by external factors during chemotaxis. Myosin filaments at the side and in the rear inhibit pseudopod formation, while Arp2/3-Scar induced F-actin in the front stimulates pseudopod formation. Several signaling pathways have been elucidated regulating the place of pseudopods formation. During chemotaxis, pseudopods are preferentially made at the side of the cell facing the highest concentration of chemoattractant, and cells move with persistence and direction. In polarized cells new pseudopods are preferentially formed at a stable front close to previous pseudopods, and inhibited at the side and in the rear of the cell, resulting in movement with strong persistence, but not in a specific direction. Unpolarized cells start new protrusions at nearly random positions, resulting in near Brownian motion. Therefore, the path of a moving cell depends on the time and place where a series of pseudopods are formed. Pseudopods are extended perpendicular to the cell surface.
In mesenchymal-type cells such as fibroblast, the protrusions are in the form of filopodia and lamellipodia that extend much slower but with strong attachment to the substratum fibroblast slowly close a wound at a rate of about 0.5 μm/min.
In amoeboid cells, such as neutrophils and Dictyostelium, these protrusions are in the form of pseudopods that extend fast at a high frequency neutrophils rapidly move to areas with infections at a rate of about 10 μm/min. However, in most cells the protrusions are transient with a short phase of extension and filling with cytoplasm, followed by the formation of a new protrusion. These protrusions can be long-lived as in keratocytes, which glide with a single broad anterior protrusion that is continuously extending and filled with cytoplasm. Upon flow of cytoplasm into the protrusion, the center of mass of the cell displaces and the cell has effectively moved in the direction of the extending protrusion.
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Please enter security code that you see on the above box.Many eukaryotic cells move by making protrusion. Send me an email when anyone response to this However, if you wish to receive a response, please include your email and name. Sharing your feedback about this process or ask for help Just press esc after the startup screen and then select boot without loader My sys reboots again and again and can't go further then dell logo? Help me quick. I just see the logo of the manufacturer (HP) and then it restarts over and over again. I used this to activate my W7 but now my computer doesn't boot at all.
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